Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet feeding.

ABSTRACT: OBJECTIVES:The nuclear receptor superfamily is a potential target for the development of new treatments for obesity and metabolic diseases. Increasing evidence has pointed towards the retinoic acid-related orphan receptor-alpha (RORα) as an important nuclear receptor involved in several biological processes. RORα full body knockout mice display improved metabolic phenotypes on both chow and high fat (60% fat, 20% carbohydrate) diets, but also have severe behavioral abnormalities. Here we investigated the effect of hepatic RORα by generating mice with liver-specific RORα deletion to elucidate the role of this nuclear receptor on host metabolism. METHODS:8 week-old mice with liver-specific RORα deletion and littermate controls were fed either chow or western-style diets (40% fat, 40% carbohy

SUBMITTER: Molinaro A 

PROVIDER: S-EPMC6479759 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature