Anisotropic Gold Nanoparticle-Cell Interactions Mediated by Collagen.

ABSTRACT: Gold nanoparticles (AuNPs) are the groundwork of a large variety of applications in the biomedical field. Further development and a better understanding of this versatile platform will lead to an expansion of potential applications. In this study, we propose a facile synthesis of AuNPs using hydrogen peroxide as a reducing agent and collagen as a stabilizing agent. Our synthetic approach results in "raspberry"-like AuNPs with a mean diameter of 60 nm, as revealed by electron microscopy. The optical properties of the AuNPs were assessed by UV-Vis and surface-enhanced Raman scattering (SERS), and their stability and in vitro cytotoxicity were evaluated as well. HeLa cell viability values were only modestly affected compared to control, with the highest concentration tested displaying a 20% d

SUBMITTER: Marisca OT 

PROVIDER: S-EPMC6480049 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature