Increased Expression of Cell Surface SSEA-1 is Closely Associated with Naive-Like Conversion from Human Deciduous Teeth Dental Pulp Cells-Derived iPS Cells.

ABSTRACT: Stage-specific embryonic antigen 1 (SSEA-1) is an antigenic epitope (also called CD15 antigen) defined as a Lewis X carbohydrate structure and known to be expressed in murine embryonal carcinoma cells, mouse embryonic stem cells (ESCs), and murine and human germ cells, but not human ESCs/induced pluripotent stem cells (iPSCs). It is produced by α1,3-fucosyltransferase IX gene (FUT9), and F9 ECCs having a disrupted FUT9 locus by gene targeting are reported to exhibit loss of SSEA-1 expression on their cell surface. Mouse ESCs are pluripotent cells and therefore known as "naïve stem cells (NSCs)." In contrast, human ESCs/iPSCs are thought to be epiblast stem cells (EpiSCs) that are slightly more differentiated than NSCs. Recently, it has been demonstrated that treatment of EpiS

SUBMITTER: Inada E 

PROVIDER: S-EPMC6480091 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature