Two Component Regulatory Systems and Antibiotic Resistance in Gram-Negative Pathogens.

ABSTRACT: Gram-negative pathogens such as Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa are the leading cause of nosocomial infections throughout the world. One commonality shared among these pathogens is their ubiquitous presence, robust host-colonization and most importantly, resistance to antibiotics. A significant number of two-component systems (TCSs) exist in these pathogens, which are involved in regulation of gene expression in response to environmental signals such as antibiotic exposure. While the development of antimicrobial resistance is a complex phenomenon, it has been shown that TCSs are involved in sensing antibiotics and regulating genes associated with antibiotic resistance. In this review, we aim to interpret current knowledge abou

SUBMITTER: Bhagirath AY 

PROVIDER: S-EPMC6480566 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature