Gene duplications in the E. coli genome: common themes among pathotypes.

ABSTRACT:

Background

Gene duplication underlies a significant proportion of gene functional diversity and genome complexity in both eukaryotes and prokaryotes. Although several reports in the literature described the duplication of specific genes in E. coli, a detailed analysis of the extent of gene duplications in this microorganism is needed.

Results

The genomes of the E. coli enteroaggregative strain 042 and other pathogenic strains contain duplications of the gene that codes for the global regulator Hha. To determine whether the presence of additional copies of the hha gene correlates with the presence of other genes, we performed a comparative genomic analysis between E. coli strains with and without hha duplications. The results showed that strains harboring additional copies of

SUBMITTER: Bernabeu M 

PROVIDER: S-EPMC6480617 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature