Comprehensive kinome NGS targeted expression profiling by KING-REX.

ABSTRACT:

Background

Protein kinases are enzymes controlling different cellular functions. Genetic alterations often result in kinase dysregulation, making kinases a very attractive class of druggable targets in several human diseases. Existing approved drugs still target a very limited portion of the human 'kinome', demanding a broader functional knowledge of individual and co-expressed kinase patterns in physiologic and pathologic settings. The development of novel rapid and cost-effective methods for kinome screening is therefore highly desirable, potentially leading to the identification of novel kinase drug targets.

Results

In this work, we describe the development of KING-REX (KINase Gene RNA EXpression), a comprehensive kinome RNA targeted custom assay-based panel designed for

SUBMITTER: Carapezza G 

PROVIDER: S-EPMC6480677 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature