Association of TNFAIP8 gene polymorphisms with endometrial cancer in northern Chinese women.

ABSTRACT:

Background

Tumor necrosis factor-a-induced protein 8 (TNFAIP8) presented a elevated expression in endometrial cancer (EC). However, the relationship of TNFAIP8 gene polymorphisms with EC risk remains unclear. This case-control study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) in TNFAIP8 on northern Chinese women with EC.

Methods

SNP rs11064, rs1045241, and rs1045242 in TNFAIP8 were successfully genotyped in 248 cancer-free controls and 226 ECs by SNaPshot method, respectively. Logistic regression was performed to assess relationship of SNPs with EC risk. The relationships of SNPs with clinicopathological variables were evaluated by Chi-square test or Student's t-test or Fisher's text.

Results

The minor alleles of rs11064 in TNFAIP8 were s

SUBMITTER: Liu T 

PROVIDER: S-EPMC6480735 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature