Late immune consequences of combat trauma: a review of trauma-related immune dysfunction and potential therapies.

ABSTRACT: With improvements in personnel and vehicular body armor, robust casualty evacuation capabilities, and damage control resuscitation strategies, more combat casualties are surviving to reach higher levels of care throughout the casualty evacuation system. As such, medical centers are becoming more accustomed to managing the deleterious late consequences of combat trauma related to the dysregulation of the immune system. In this review, we aim to highlight these late consequences and identify areas for future research and therapeutic strategies. Trauma leads to the dysregulation of both the innate and adaptive immune responses, which places the injured at risk for several late consequences, including delayed wound healing, late onset sepsis and infection, multi-organ dysfunction syndrome, and

SUBMITTER: Thompson KB 

PROVIDER: S-EPMC6480837 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature