Control of respiratory drive by extracorporeal CO₂ removal in acute exacerbation of COPD breathing on non-invasive NAVA.

ABSTRACT:

Background

Veno-venous extracorporeal CO₂ removal (vv-ECCO₂R) and non-invasive neurally adjusted ventilator assist (NIV-NAVA) are two promising techniques which may prevent complications related to prolonged invasive mechanical ventilation in patients with acute exacerbation of COPD.

Methods

A physiological study of the electrical activity of the diaphragm (Edi) response was conducted with varying degrees of extracorporeal CO₂ removal to control the respiratory drive in patients with severe acute exacerbation of COPD breathing on NIV-NAVA.

Results

Twenty COPD patients (SAPS II 37 ± 5.6, age 57 ± 9 years) treated with vv-ECCO₂R and supported by NIV-NAVA were studied during stepwise weaning of vv-ECCO₂R. Based on dy

SUBMITTER: Karagiannidis C 

PROVIDER: S-EPMC6480839 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature