TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression.

ABSTRACT:

Background

Genome-wide association studies have identified over 160 loci that are associated with coronary artery disease. As with other complex human diseases, risk in coronary disease loci is determined primarily by altered expression of the causal gene, due to variation in binding of transcription factors and chromatin-modifying proteins that directly regulate the transcriptional apparatus. We have previously identified a coronary disease network downstream of the disease-associated transcription factor TCF21, and in work reported here extends these studies to investigate the mechanisms by which it interacts with the AP-1 transcription complex to regulate local epigenetic effects in these downstream coronary disease loci.

Methods

Genomic studies, including chromatin immun

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC6480881 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature