Imaging Biomarkers as Predictors for Breast Cancer Death.

ABSTRACT:

Background

To differentiate the risk of breast cancer death in a longitudinal cohort using imaging biomarkers of tumor extent and biology, specifically, the mammographic appearance, basal phenotype, histologic tumor distribution, and conventional tumor attributes.

Methods

Using a prospective cohort study design, 498 invasive breast cancer patients diagnosed between 1996 and 1998 were used as the test cohort to assess the independent effects of the imaging biomarkers and other predictors on the risk of breast cancer death. External validation was performed with a cohort of 848 patients diagnosed between 2006 and 2010.

Results

Mammographic tumor appearance was an independent predictor of risk of breast cancer death (P=0.0003) when conventional tumor attributes and treat

SUBMITTER: Wu WY 

PROVIDER: S-EPMC6481030 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature