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Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata.

ABSTRACT: Six novel lactone derivatives, cryptolaevilactones A-F (1-6), were isolated from Cryptocarya laevigata. Their unique spiro[3.5]nonane moiety by hetero [2 + 2] cyclization with monoterpene and polyketide was found for the first time in nature. Structural elucidation using various nuclear magnetic resonance (NMR) techniques revealed that 1-3 and 4-6 are diastereomers and partially established the absolute configurations.

SUBMITTER: Tsurumi F

PROVIDER: S-EPMC6481162 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata.

Tsurumi Fumika F Miura Yuta Y Saito Yohei Y Miyake Katsunori K Fujie Tetsuo T Newman David J DJ O'Keefe Barry R BR Lee Kuo-Hsiung KH Nakagawa-Goto Kyoko K

Organic letters 20180406 8

Six novel lactone derivatives, cryptolaevilactones A-F (1-6), were isolated from Cryptocarya laevigata. Their unique spiro[3.5]nonane moiety by hetero [2 + 2] cyclization with monoterpene and polyketide was found for the first time in nature. Structural elucidation using various nuclear magnetic resonance (NMR) techniques revealed that 1-3 and 4-6 are diastereomers and partially established the absolute configurations. ...[more]

PMID: 29624062

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