A Tool for Computation of Changes in Na⁺, K⁺, Cl^- Channels and Transporters Due to Apoptosis by Data on Cell Ion and Water Content Alteration.

ABSTRACT: Monovalent ions are involved in a vast array of cellular processes. Their movement across the cell membrane is regulated by numerous channels and transporters. Identification of the pathways responsible for redistribution of ions and cell water in living cells is hampered by their strong interdependence. This difficulty can be overcome by computational analysis of the whole cell flux balance. Our previous computational studies were concerned with monovalent ion fluxes in cells under the conditions of balanced ion distribution or during transition processes after stopping the Na⁺/K⁺ pump. Here we analyze a more complex case-redistribution of ions during cell apoptosis when the parameters keep changing during the process. New experimental data for staurosporine-induced

SUBMITTER: Yurinskaya VE 

PROVIDER: S-EPMC6481184 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature