Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium.

ABSTRACT:

Objective

To evaluate the associations between adiposity measures (body mass index, waist circumference, and waist-to-height ratio) with decline in glomerular filtration rate (GFR) and with all cause mortality.

Design

Individual participant data meta-analysis.

Setting

Cohorts from 40 countries with data collected between 1970 and 2017.

Participants

Adults in 39 general population cohorts (n=5 459 014), of which 21 (n=594 496) had data on waist circumference; six cohorts with high cardiovascular risk (n=84 417); and 18 cohorts with chronic kidney disease (n=91 607).

Main outcome measures

GFR decline (estimated GFR decline ≥40%, initiation of kidney replacement therapy or estimated GFR <10 mL/min/1.73 m²) and all cause mortality.

Results

SUBMITTER: Chang AR 

PROVIDER: S-EPMC6481269 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature