Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration.

ABSTRACT: During both embryonic development and adult tissue regeneration, changes in chromatin structure driven by master transcription factors lead to stimulus-responsive transcriptional programs. A thorough understanding of how stem cells in the skeleton interpret mechanical stimuli and enact regeneration would shed light on how forces are transduced to the nucleus in regenerative processes. Here we develop a genetically dissectible mouse model of mandibular distraction osteogenesis-which is a process that is used in humans to correct an undersized lower jaw that involves surgically separating the jaw bone, which elicits new bone growth in the gap. We use this model to show that regions of newly formed bone are clonally derived from stem cells that reside in the skeleton. Using chromatin and tran

SUBMITTER: Ransom RC 

PROVIDER: S-EPMC6481292 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature