Assessment of mesoscopic properties of deep gray matter iron through a model-based simultaneous analysis of magnetic susceptibility and R₂* - A pilot study in patients with multiple sclerosis and normal controls.

ABSTRACT: Most studies of brain iron relied on the effect of the iron on magnetic resonance (MR) relaxation properties, such as R₂^∗, and bulk tissue magnetic susceptibility, as measured by quantitative susceptibility mapping (QSM). The present study exploited the dependence of R₂^∗ and magnetic susceptibility on physical interactions at different length-scales to retrieve information about the tissue microenvironment, rather than the iron concentration. We introduce a method for the simultaneous analysis of brain tissue magnetic susceptibility and R₂^∗ that aims to isolate those biophysical mechanisms of R₂^∗ -contrast that are associated with the micro- and mesoscopic distribution of iron, referred to as the Iron M

SUBMITTER: Taege Y 

PROVIDER: S-EPMC6481304 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature