Phospholipid profiles and hepatocellular carcinoma risk and prognosis in cirrhotic patients.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Phospholipids are now well-recognised players in tumour progression. Their metabolic tissue alterations can be associated with plasmatic modifications. The aim of this study was to evaluate the potential of the plasma phospholipid profile as a risk and prognostic biomarker in HCC.

Methods

Ninety cirrhotic patients with (cases) or without HCC (controls) were studied after matching for inclusion centre, age, gender, virus infection, cirrhosis duration and Child-Pugh grade. High-performance liquid chromatography coupled with tandem-mass spectrometry was used to quantify the main species of seven categories of phospholipids in plasma.

Results

Elevated concentrations of phosphatidylcholine

SUBMITTER: Cotte AK 

PROVIDER: S-EPMC6481329 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature