Mendelian randomization study shows no causal relationship between circulating urate levels and Parkinson's disease.

ABSTRACT:

Objective

Observational studies have shown that increased plasma urate is associated with lower risk of Parkinson's disease (PD), but these studies were not designed to test causality. If a causal relationship exists, then modulating plasma urate levels could be a potential preventive avenue for PD. We used a large two-sample Mendelian randomization (MR) design to assess for a causal relationship between plasma urate and PD risk.

Methods

We used a genetic instrument consisting of 31 independent loci for plasma urate on a case-control genome-wide association study data set, which included 13,708 PD cases and 95,282 controls. Individual effect estimates for each SNP were combined using the inverse-variance weighted (IVW) method. Two additional methods, MR-Egger and a penalized

SUBMITTER: Kia DA 

PROVIDER: S-EPMC6481555 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature