Comparison of Risk of Osteoporotic Fracture in Denosumab vs Alendronate Treatment Within 3 Years of Initiation.

ABSTRACT:

Importance

Head-to-head randomized clinical trials showed greater efficacy of denosumab vs alendronate in improving bone mineral density. Although there is an association of changes in bone mineral density with reductions in fracture risk, the magnitude of the association is not well established.

Objective

To compare the risk of hip and any fracture in patients treated with denosumab and alendronate in routine practice settings.

Design, setting, and participants

This Danish nationwide, population-based, historical cohort study of a population with universal access to health care used prospectively collected, individually linked data from Danish health registries with complete follow-up. Cohorts consisted of 92 355 individuals 50 years or older who were new users of de

SUBMITTER: Pedersen AB 

PROVIDER: S-EPMC6481596 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature