Refining Prediction of Atrial Fibrillation-Related Stroke Using the P₂-CHA₂DS₂-VASc Score.

ABSTRACT:

Background

In people with atrial fibrillation (AF), periods of sinus rhythm present an opportunity to detect prothrombotic atrial remodeling through measurement of P-wave indices (PWIs)-prolonged P-wave duration, abnormal P-wave axis, advanced interatrial block, and abnormal P-wave terminal force in lead V1. We hypothesized that the addition of PWIs to the CHA₂DS₂-VASc score would improve its ability to predict AF-related ischemic stroke.

Methods

We included 2229 participants from the ARIC study (Atherosclerosis Risk in Communities) and 700 participants from MESA (Multi-Ethnic Study of Atherosclerosis) with incident AF who were not on anticoagulants within 1 year of AF diagnosis. PWIs were obtained from study visit ECGs before development of AF. AF was

SUBMITTER: Maheshwari A 

PROVIDER: S-EPMC6481672 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature