Total cholesterol variability and risk of atrial fibrillation: A nationwide population-based cohort study.

ABSTRACT:

Background

Long-term variability of cardiometabolic risk factors have been suggested as the risk factors for cardiovascular disease and mortality. However, the effect of long-term variability of total cholesterol (TC) on incident atrial fibrillation (AF) has not been examined.

Methods and findings

We explored whether visit-to-visit TC variability are associated with the risk of incident AF in 160,165 Korean adults, using the population-based Korean National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) database, over a median duration of 8.4 years. TC variability was measured as coefficients of variance (TC-CV), standard deviation (TC-SD), and variability independent of the mean (TC-VIM). Kaplan-Meier analysis demonstrated a decreased disease-free probability

SUBMITTER: Roh E 

PROVIDER: S-EPMC6481829 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature