Biomarkers of basal cell carcinoma resistance to methyl-aminolevulinate photodynamic therapy.

ABSTRACT:

Background

Methyl-aminolevulinate photodynamic therapy (MAL-PDT) is an excellent option for the treatment of basal cell carcinoma (BCC). However, up to 25% of cases are resistant to this treatment modality.

Objective

The aim of this study was to identify potential biomarkers of BCC response to MAL-PDT.

Material and methods

Clinical, histological, and immunohistochemical (p53, Ki-67, CD-31, COX2, β-catenin, EGFR, and survivin) variables were analyzed in a retrospective study of consecutive BCC patients treated with MAL-PDT at the San Jorge Hospital, Huesca, Spain between January 2006 and December 2015. To deepen on these markers, the effects on p53 and cyclin D1 expression, in vitro response to MAL-PDT of 2 murine BCC cell lines (ASZ and BSZ), was also evaluated.

Re

SUBMITTER: Gracia-Cazana T 

PROVIDER: S-EPMC6481917 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature