Mutant huntingtin enhances activation of dendritic Kv4 K⁺ channels in striatal spiny projection neurons.

ABSTRACT: Huntington's disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs). To better understand the mechanisms underlying this deficit, striatal neurons in ex vivo brain slices from mouse genetic models of HD were studied using electrophysiological, optical and biochemical approaches. Distal dendrites of iSPNs from symptomatic HD mice were hypoexcitable, a change that was attributable to increased association of dendritic Kv4 potassium channels with auxiliary KChIP subunits. This association was negatively modulated by TrkB receptor signaling. Dendritic excitability of HD iSPNs was rescued by knocking-down expression of Kv4 channels, by disrupting

SUBMITTER: Carrillo-Reid L 

PROVIDER: S-EPMC6481990 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature