Toward miniaturized analysis of chemical identity and purity of radiopharmaceuticals via microchip electrophoresis.

ABSTRACT: Miniaturized synthesis of positron emission tomography (PET) tracers is poised to offer numerous advantages including reduced tracer production costs and increased availability of diverse tracers. While many steps of the tracer production process have been miniaturized, there has been relatively little development of microscale systems for the quality control (QC) testing process that is required by regulatory agencies to ensure purity, identity, and biological safety of the radiotracer before use in human subjects. Every batch must be tested, and in contrast with ordinary pharmaceuticals, the whole set of tests of radiopharmaceuticals must be completed within a short-period of time to minimize losses due to radioactive decay. By replacing conventional techniques with microscale analytical

SUBMITTER: Ly J 

PROVIDER: S-EPMC6482050 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature