Dataset Information

Distress and quality of life in patient and caregiver dyads facing stem cell transplant: identifying overlap and unique contributions.

ABSTRACT:

Purpose

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is a demanding treatment requiring caregiver support. The pre-transplant period is particularly stressful. How patient and caregiver dyads respond to these stressors can impact post-transplant outcomes. The purpose of this cross-sectional study was to assess pre-transplant patient and caregiver distress, patient quality of life (pQoL), and simultaneously investigate relationship between caregiver distress, patient distress, and patient QoL.

Methods

We measured caregiver anxiety, depressive symptoms, perceived stress, sleep quality, caregiver burden, and pQoL in148 dyads compared to clinical thresholds or population norms. To reduce comparisons, we created a composite distress score from affective measures. Associations within dyads were examined via correlation and path analysis.

Results

Most dyads scored above norms for psychological measures. Patient distress was positively associated with caregiver distress. Higher caregiver distress significantly predicted poorer pQoL after accounting for the interdependence of patient and caregiver distress. Specifically, patients' physical functioning was the primary driver of this interrelationship.

Conclusions

Allo-HSCT patients and their caregivers reported elevated distress pre-transplant. Both patient and caregiver distress contributed to pQoL, with patients' physical functioning accounting significantly for caregiver well-being. Supporting the patient-caregiver dyad before transplantation is a priority for supportive services.

SUBMITTER: Sannes TS

PROVIDER: S-EPMC6482095 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Publications

Distress and quality of life in patient and caregiver dyads facing stem cell transplant: identifying overlap and unique contributions.

Sannes Timothy S TS Simoneau Teresa L TL Mikulich-Gilbertson Susan K SK Natvig Crystal L CL Brewer Benjamin W BW Kilbourn Kristin K Laudenslager Mark L ML

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20181024 6

<h4>Purpose</h4>Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is a demanding treatment requiring caregiver support. The pre-transplant period is particularly stressful. How patient and caregiver dyads respond to these stressors can impact post-transplant outcomes. The purpose of this cross-sectional study was to assess pre-transplant patient and caregiver distress, patient quality of life (pQoL), and simultaneously investigate relationship between caregiver distress, patient dis ...[more]

PMID: 30353229

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Dataset Information

Distress and quality of life in patient and caregiver dyads facing stem cell transplant: identifying overlap and unique contributions.

Purpose

Methods

Results

Conclusions

Publications

Distress and quality of life in patient and caregiver dyads facing stem cell transplant: identifying overlap and unique contributions.

Similar Datasets

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