Incidence and clinicopathologic features of H3 K27M mutations in adults with radiographically-determined midline gliomas.

ABSTRACT:

Purpose

H3 K27 mutations, most commonly in H3F3A, are common in diffuse midline glioma. The exact frequency of these mutations in adults with gliomas in the midline location is unknown. This study was conducted to define the incidence of H3 K27M mutations in this location and to compare clinicopathological features with those of patients who do not harbor this mutation.

Methods

Consecutive glioma cases from 2007 to 2017 were screened for gliomas in the midline location. Immunohistochemistry was performed on all available tissue for mutations of H3 K27M, IDH1, and ARTX.

Results

Of 850 gliomas screened, 163 cases had midline glioma on MRI. Sufficient FFPE tissue was available for 123 cases (75%). H3 K27M mutation was identified in 18 of 123 cases (15%). All except one H

SUBMITTER: Schreck KC 

PROVIDER: S-EPMC6482123 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature