Cancer and cancer survival modulates brain and behavior in a time-of-day-dependent manner in mice.

ABSTRACT: Improvements in breast cancer therapy/diagnosis have substantially increased the cancer survivor population, although many survivors report persistent mental health issues including fatigue, mood and anxiety disorders, and cognitive impairments. These behavioral symptoms impair quality-of-life and are often associated with increased inflammation. Nocturnal rodent models of cancer are critical to the identification of the neurobiological mechanisms underlying these behavioral changes. Although both behavior and immunity display distinct diurnal patterns, most rodent research in this field is performed during the rodents' inactive (light) period, which could potentially undermine the conclusions and clinical relevance. Therefore, here we tested the extent to which mammary tumors or tumor res

SUBMITTER: Santos JC 

PROVIDER: S-EPMC6482139 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature