Insulin-dependent GLUT4 trafficking is not regulated by protein SUMOylation in L6 myocytes.

ABSTRACT: Type-II Diabetes Mellitus (T2DM) is one of the fastest growing public health issues today, consuming 12% of worldwide health budgets and affecting an estimated 400 million people. One of the key pathological traits of this disease is insulin resistance at 'glucose sink' tissues (mostly skeletal muscle), and this remains one of the features of this disease most intractable to therapeutic intervention. Several lines of evidence have implicated the post-translational modification, SUMOylation, in insulin signalling and insulin resistance in skeletal muscle. In this study, we examined this possibility by manipulation of cellular SUMOylation levels using multiple different tools, and assaying the effect on insulin-stimulated GLUT4 surface expression in differentiated L6 rat myocytes. Although i

SUBMITTER: Carmichael RE 

PROVIDER: S-EPMC6482176 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature