BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival.

ABSTRACT: Malignant melanoma is one of the most difficult cancers to treat due to its resistance to chemotherapy. Despite recent successes with BRAF inhibitors and immune checkpoint inhibitors, many patients do not respond or become resistant to these drugs. Hence, alternative treatments are still required. Due to the importance of the BCL-2-regulated apoptosis pathway in cancer development and drug resistance, it is of interest to establish which proteins are most important for melanoma cell survival, though the outcomes of previous studies have been conflicting. To conclusively address this question, we tested a panel of established and early passage patient-derived cell lines against several BH3-mimetic drugs designed to target individual or subsets of pro-survival BCL-2 proteins, alone and in co

SUBMITTER: Lee EF 

PROVIDER: S-EPMC6482196 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature