Stressful Newborn Memories: Pre-Conceptual, In Utero, and Postnatal Events.

ABSTRACT: Early-life stressful experiences are critical for plasticity and development, shaping adult neuroendocrine response and future health. Stress response is mediated by the autonomous nervous system and the hypothalamic-pituitary-adrenal (HPA) axis while various environmental stimuli are encoded via epigenetic marks. The stress response system maintains homeostasis by regulating adaptation to the environmental changes. Pre-conceptual and in utero stressors form the fetal epigenetic profile together with the individual genetic profile, providing the background for individual stress response, vulnerability, or resilience. Postnatal and adult stressful experiences may act as the definitive switch. This review addresses the issue of how preconceptual in utero and postnatal ev

SUBMITTER: Papadopoulou Z 

PROVIDER: S-EPMC6482218 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature