Reproducibility of Quantitative Systems Pharmacology Models: Current Challenges and Future Opportunities.

ABSTRACT: The provision of model code is required for publication in CPT: Pharmacometrics & Systems Pharmacology, enabling quantitative systems pharmacology (QSP) model availability. A searchable repository of published QSP models would enhance model accessibility. We assess the feasibility of establishing such a resource based on 18 QSP models published in this journal. However, because of the diversity of software platforms (nine), file formats, and functionality, such a resource is premature. We evaluated 12 of the models (those coded in R, PK-Sim/MoBi, and MATLAB) for functionality. Of the 12, only 4 were executable in that figures from the associated manuscript could be generated via a "run" script. Many researchers are aware of the challenges involved in repurposing published models. We offer

SUBMITTER: Kirouac DC 

PROVIDER: S-EPMC6482280 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature