Comparison of two serum free light chain assays for the diagnosis of primary plasma cell malignant proliferative disease.

ABSTRACT:

Background and aims

The serum free light chain assay (sFLC) is well established for aiding in the diagnosis, prognosis, and monitoring of plasma cell proliferative disorders. There are currently two commercially available sFLC immunoassays, Freelite, based on polyclonal antibody technology, and N Latex FLC, based on monoclonal antibodies. This study aimed to compare the analytical and clinical performance of these two assays in a Chinese population.

Methods

This study included 74 consecutive patients who were newly diagnosed with monoclonal gammopathies (MGs) including multiple myeloma (MM), AL amyloidosis, and light chain deposition disease (LCDD) between January 2014 and May 2015 at the First Affiliated Hospital of Zhejiang University. Alongside serum and urine electrophor

SUBMITTER: Yang Y 

PROVIDER: S-EPMC6482328 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature