Genetic Variation in Pan Species Is Shaped by Demographic History and Harbors Lineage-Specific Functions.

ABSTRACT: Chimpanzees (Pan troglodytes) and bonobos (Pan paniscus) are the closest living relatives of humans, but the two species show distinct behavioral and physiological differences, particularly regarding female reproduction. Despite their recent rapid decline, the demographic histories of the two species have been different during the past 1-2 Myr, likely having an impact on their genomic diversity. Here, we analyze the inferred functional consequences of genetic variation across 69 individuals, making use of the most complete data set of genomes in the Pan clade to date. We test to which extent the demographic history influences the efficacy of purifying selection in these species. We find that small historical effective population sizes (Ne) correlate not only with low levels of genetic dive

SUBMITTER: Han S 

PROVIDER: S-EPMC6482415 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature