Peptide-based capsules with chirality-controlled functionalized interiors - rational design and amplification from dynamic combinatorial libraries.

ABSTRACT: Peptides are commonly perceived as inapplicable components for construction of porous structures. Due to their flexibility the design is difficult and shape persistence of such putative structures is diminished. Notwithstanding these limitations, the advantages of peptides as building blocks are numerous: they are functional and functionalizable, widely available, diverse and biocompatible. We aimed at the construction of discrete porous structures that exploit the inherent functionality of peptides by an approach that is inspired by nature: structural pockets are defined by the backbones of peptides while functionality is introduced by their side chains. In this work peptide ribbons were preorganized on a macrocyclic scaffold using azapeptide-aldehyde reactions. The resulting cavitands wi

SUBMITTER: Jedrzejewska H 

PROVIDER: S-EPMC6482442 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature