Methods for quantitative characterization of bone injury from computed-tomography images.

ABSTRACT: Computed tomography (CT) images can potentially provide insights into bone structure for diagnosis of disorders and diseases. However, evaluation of trabecular bone structure and whole bone shape is often qualitative or semi-quantitative. This limits inter-study comparisons and the ability to detect subtle bone quality variations during early disease onset or in response to new treatments. In this work, we enable quantitative characterization of bone diseases through bone morphometry, texture analysis, and shape analysis methods. The potential of our analysis methods to identify the impact of hemophilia is validated in a mouse femur wound model. In our results, shape localizes and characterizes the formation of spurious bone, and our texture and bone morphometry analysis results provide ex

SUBMITTER: Hernandez-Cerdan P 

PROVIDER: S-EPMC6482455 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature