Stratification of cancer and diabetes based on circulating levels of formate and glucose.

ABSTRACT:

Background

Serum and urine metabolites have been investigated for their use as cancer biomarkers. The specificity of candidate metabolites can be limited by the impact of other disorders on metabolite levels. In particular, the increasing incidence of obesity could become a significant confounding factor.

Methods

Here we developed a multinomial classifier for the stratification of cancer, obesity and healthy phenotypes based on circulating glucose and formate levels. We quantified the classifier performance from the retrospective analysis of samples from breast cancer, lung cancer, obese individuals and healthy controls.

Results

We discovered that circulating formate levels are significantly lower in breast and lung cancer patients than in healthy controls. However, t

SUBMITTER: Pietzke M 

PROVIDER: S-EPMC6482583 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature