Longitudinal cortical network reorganization in early relapsing-remitting multiple sclerosis.

ABSTRACT:

Background

Network science provides powerful access to essential organizational principles of the brain. The aim of this study was to investigate longitudinal evolution of gray matter networks in early relapsing-remitting MS (RRMS) compared with healthy controls (HCs) and contrast network dynamics with conventional atrophy measurements.

Methods

For our longitudinal study, we investigated structural cortical networks over 1 year derived from 3T MRI in 203 individuals (92 early RRMS patients with mean disease duration of 12.1 ± 14.5 months and 101 HCs). Brain networks were computed based on cortical thickness inter-regional correlations and fed into graph theoretical analysis. Network connectivity measures (modularity, clustering coefficient, local efficiency, and transitivity

SUBMITTER: Fleischer V 

PROVIDER: S-EPMC6482642 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature