Elevated renalase levels in patients with acute coronary microvascular dysfunction - A possible biomarker for ischemia.

ABSTRACT:

Aims

We explored the relationship between inflammation, renalase an anti-inflammatory protein, and acute chest pain with coronary microvascular dysfunction (CMD).

Methods and results

We used cardiac Rb-82 PET/CT imaging to diagnose coronary artery disease (CAD/CALC) (defect or coronary calcification) and CMD (depressed coronary flow reserve without CAD) in patients with chest pain in an emergency department (ED). Blood samples were collected pre-imaging within 24 h of ED presentation and were analyzed for renalase and inflammatory markers including C-reactive protein, interleukins, interferon gamma, tumor necrosis factor, vascular endothelial growth factor, and metalloproteinases. Exclusions were age ≤30 years, myocardial infarction, hemodynamic instability, hypertensive cri

SUBMITTER: Safdar B 

PROVIDER: S-EPMC6482834 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature