Preparation and evaluation of ^99mTc-labeled porphyrin complexes prepared using PNP and HYNIC cores: studying the effects of core selection on pharmacokinetics and tumor uptake in a mouse model.

ABSTRACT: Porphyrins are tetrapyrrolic macrocyclic ligands known for their affinity towards neoplastic tissues and once radiolabeled with a suitable diagnostic radioisotope could potentially be used for the imaging of tumorous lesions. In the present study, an unsymmetrically substituted porphyrin derivative namely 5-(p-amino-propyloxyphenyl)-10,15,20-tris(carboxymethyleneoxyphenyl)-porphyrin was synthesized and modified further to enable radiolabeling with ^99mTc using two different ^99mTc-cores viz. ^99mTc-HYNIC (hydrazino nicotinic acid) and ^99mTc(N)PNP2 (PNP2 = bis-[(2-dimethylphosphino)ethyl]-methoxy-ethylamine) in order to study the effect of employing different ^99mTc-cores on tumor affinity and pharmacokinetic behavior of the r

SUBMITTER: Guleria M 

PROVIDER: S-EPMC6482877 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature