The Plasma NAD⁺ Metabolome Is Dysregulated in "Normal" Aging.

ABSTRACT: Nicotinamide adenine dinucleotide (NAD⁺) is an essential pyridine nucleotide that serves as an electron carrier in cellular metabolism and plays a crucial role in the maintenance of balanced redox homeostasis. Quantification of NAD⁺:NADH and NADP⁺:NADPH ratios are pivotal to a wide variety of cellular processes, including intracellular secondary messenger signaling by CD38 glycohydrolases, DNA repair by poly(adenosine diphosphate ribose) polymerase (PARP), epigenetic regulation of gene expression by NAD-dependent histone deacetylase enzymes known as sirtuins, and regulation of the oxidative pentose phosphate pathway. We quantified changes in the NAD⁺ metabolome in plasma samples collected from consenting healthy human subjects across a wide age r

SUBMITTER: Clement J 

PROVIDER: S-EPMC6482912 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature