Resolution of Hypothyroidism Restores Cold-Induced Thermogenesis in Humans.

ABSTRACT:

Background

Hypothyroidism is a frequent endocrine disorder with common symptoms of increased cold sensitivity and unintended weight gain, indicating changes in energy expenditure (EE) and response to cold exposure. Thyroid hormones (TH) play an important role for proper function of brown adipose tissue (BAT) and cold-induced thermogenesis (CIT) in rodents, but the role of hypothyroidism on CIT in humans is uncertain.

Methods

This was a prospective observational study. Forty-two patients presenting with subclinical or overt hypothyroidism in whom TH replacement was planned were recruited. Thirty-three patients completed the study. Thermogenesis was measured by indirect calorimetry during warm conditions and after a mild cold stimulus of 90 minutes, both during the hypothyroid

SUBMITTER: Maushart CI 

PROVIDER: S-EPMC6482913 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature