Entry Exclusion of Conjugative Plasmids of the IncA, IncC, and Related Untyped Incompatibility Groups.

ABSTRACT: Conjugative plasmids of incompatibility group C (IncC), formerly known as A/C₂, disseminate antibiotic resistance genes globally in diverse pathogenic species of Gammaproteobacteria. Salmonella genomic island 1 (SGI1) can be mobilized by IncC plasmids and was recently shown to reshape the conjugative type IV secretion system (T4SS) encoded by these plasmids to evade entry exclusion. Entry exclusion blocks DNA translocation between cells containing identical or highly similar plasmids. Here, we report that the protein encoded by the entry exclusion gene of IncC plasmids (eexC) mediates entry exclusion in recipient cells through recognition of the IncC-encoded TraG_C protein in donor cells. Phylogenetic analyses based on EexC and TraG_C homologs p

SUBMITTER: Humbert M 

PROVIDER: S-EPMC6482922 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature