A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics.

ABSTRACT: Idiopathic intracranial hypertension (IIH) is a condition of unknown etiology, characterized by elevated intracranial pressure frequently manifesting with chronic headaches and visual loss. Similar to polycystic ovary syndrome (PCOS), IIH predominantly affects obese women of reproductive age. In this study, we comprehensively examined the systemic and cerebrospinal fluid (CSF) androgen metabolome in women with IIH in comparison with sex-, BMI-, and age-matched control groups with either simple obesity or PCOS (i.e., obesity and androgen excess). Women with IIH showed a pattern of androgen excess distinct to that observed in PCOS and simple obesity, with increased serum testosterone and increased CSF testosterone and androstenedione. Human choroid plexus expressed the androgen receptor, alo

SUBMITTER: O'Reilly MW 

PROVIDER: S-EPMC6483000 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature