Skin cancer precursor immunotherapy for squamous cell carcinoma prevention.

ABSTRACT:

Background

Topical calcipotriol plus 5-fluorouracil (5-FU) combination is an effective immunotherapy against actinic keratosis (AK), which is a precursor to squamous cell carcinoma (SCC). However, the long-term effectiveness of calcipotriol plus 5-FU treatment for SCC prevention is unknown.

Methods

We performed a blinded prospective cohort study on participants of a randomized double-blind clinical trial in which a 4-day course of topical calcipotriol plus 5-FU combination was compared to Vaseline plus 5-FU (control) for AK treatment. SCC and basal cell carcinoma (BCC) incidences were assessed at 1, 2, and 3 years after trial. Tissues were analyzed for calcipotriol plus 5-FU-induced T cell immunity in the skin.

Results

Calcipotriol plus 5-FU-induced tissue-resident me

SUBMITTER: Rosenberg AR 

PROVIDER: S-EPMC6483001 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature