Lifetime discrimination burden, racial discrimination, and subclinical cerebrovascular disease among African Americans.

ABSTRACT:

Objective

Explore interactive relations of lifetime discrimination burden and racial discrimination-chronic stressors among African Americans (AAs)-and age with MRI-assessed white matter lesion volume (WMLV), a prognostic indicator of poor clinical brain health outcomes.

Method

AAs (N = 71; 60.6% female, mean age = 50) participating in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) SCAN study underwent quantitative magnetic resonance imaging coded for WMLV. Participants self-reported lifetime discrimination burden and racial discrimination approximately 5 years earlier. Multivariable regression models assessed interactions of linear and quadratic effects of discrimination and age with WMLV adjusted for sex and socioeconomic status.

Results</

SUBMITTER: Beatty Moody DL 

PROVIDER: S-EPMC6483094 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature