Mechanisms of in utero cortisol effects on the newborn heart revealed by transcriptomic modeling.

ABSTRACT: We have identified effects of elevated maternal cortisol (induced by maternal infusion 1 mg·kg^-1·day^-1) on fetal cardiac maturation and function using an ovine model. Whereas short-term exposure (115-130-day gestation) increased myocyte proliferation and Purkinje fiber apoptosis, infusions until birth caused bradycardia with increased incidence of arrhythmias at birth and increased perinatal death, despite normal fetal cortisol concentrations from 130 days to birth. Statistical modeling of the transcriptomic changes in hearts at 130 and 140 days suggested that maternal cortisol excess disrupts cardiac metabolism. In the current study, we modeled pathways in the left ventricle (LV) and interventricular septum (IVS) of newborn lambs after maternal cortisol infusion from

SUBMITTER: Antolic A 

PROVIDER: S-EPMC6483213 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature