Resting state functional connectivity patterns associated with pharmacological treatment resistance in temporal lobe epilepsy.

ABSTRACT: There are no functional imaging based biomarkers for pharmacological treatment response in temporal lobe epilepsy (TLE). In this study, we investigated whether there is an association between resting state functional brain connectivity (RsFC) and seizure control in TLE. We screened a large database containing resting state functional magnetic resonance imaging (Rs-fMRI) data from 286 epilepsy patients. Patient medical records were screened for seizure characterization, EEG reports for lateralization and location of seizure foci to establish uniformity of seizure localization within patient groups. Rs-fMRI data from patients with well-controlled left TLE, patients with treatment-resistant left TLE, and healthy controls were analyzed. Healthy controls and cTLE showed similar functional conne

SUBMITTER: Pressl C 

PROVIDER: S-EPMC6483378 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature