Greater reduction in mid-treatment FDG-PET volume may be associated with worse survival in non-small cell lung cancer.

ABSTRACT:

Background and purpose

This study tested the hypotheses that 1) changes in mid-treatment fluorodeoxyglucose (FDG)-positron emission tomography (PET) parameters are predictive of overall survival (OS) and 2) mid-treatment FDG-PET-adapted treatment has the potential to improve survival in patients with non-small cell lung cancer (NSCLC).

Material and methods

Patients with stage I-III NSCLC requiring daily fractionated radiation were eligible. FDG-PET-CT scans were obtained prior to and mid-treatment with radiotherapy at 40-50 Gy. The normalized maximum standardized uptake value (NSUVmax), normalized mean SUV (NSUVmean), PET-metabolic tumor volume (MTV), total lesion glycolysis (TLG), and computed tomography-based gross tumor volume (CT-GTV) were consistently measured for all p

SUBMITTER: Kong FS 

PROVIDER: S-EPMC6483381 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature