Asymmetric Alkene and Arene Halofunctionalization Reactions in Meroterpenoid Biosynthesis.

ABSTRACT: Meroterpenoid natural products are important bioactive molecules with broad distribution throughout nature. In Streptomyces bacteria, naphthoquinone-based meroterpenoids comprise a simple yet structurally fascinating group of natural product antibiotics that are enzymatically constructed through a series of asymmetric alkene and arene halofunctionalization reactions. This account article highlights our discovery and characterization of a group of vanadium-dependent chloroperoxidase enzymes that catalyze halogen-assisted cyclization and rearrangement reactions and have inspired biomimetic syntheses of numerous meroterpenoid natural products.

SUBMITTER: Moore BS 

PROVIDER: S-EPMC6483395 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature