Long-Term Potentiation Requires a Rapid Burst of Dendritic Mitochondrial Fission during Induction.

ABSTRACT: Synaptic transmission is bioenergetically demanding, and the diverse processes underlying synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP synthesis and Ca²⁺ handling, are likely essential for plasticity. Although axonal mitochondria have been extensively analyzed, LTP is predominantly induced postsynaptically, where mitochondria are understudied. Additionally, though mitochondrial fission is essential for their function, signaling pathways that regulate fission in neurons remain poorly understood. We found that NMDAR-dependent LTP induction prompted a rapid burst of dendritic mitochondrial fission and elevations of mitochondrial matrix Ca²⁺. The fission burst was triggered by cytosolic Ca²⁺ elevation and required

SUBMITTER: Divakaruni SS 

PROVIDER: S-EPMC6483400 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature